Research work carried out within the Experimental Medicine Unit of the Faculty of Medicine of Tunis during the 2017/2018 academic year. These works are carried out by young researchers to obtain a Doctorate, Master, License or Engineering diploma.
The Experimental Medicine Unit presents an experienced team which directs research work, improves the quality of work while respecting the ethics of animal experimentation.
Thesis topics
- 1- Cellular and molecular effects of natural bioactive substances on an experimental pulmonary fibrosis model in the Wistar rat.
Thesis submitted by the student : Bahri Sana (2017)
Framed by Pr Salwa Jamel Eddine (FMT Physiology Laboratory)
In cooperation with the FMT Experimental Medicine Unit - 2- Evaluation of the toxicity of Doxorubicin on male fertility and protection by selenium and thioamide.
Directed by the student: Boussada Marwa (in progress)
Framed by Pr Michèle ElMay (FMT Histology and Embryology Laboratory)
In cooperation with the FMT Experimental Medicine Unit - 3- Experimental poisoning by gold salts, lanthanum and cerium in the female reproductive system in the Wistar rat.
Thesis submitted by the student : Badri Nedra (2017)
Framed by Pr Tkaya (FMT Physiology Laboratory)
In cooperation with the FMT Experimental Medicine Unit - 4- Evaluation of the anti-biofilm potential of a bio-hybrid (Bcl-HDL).
Supported by the student : Mekni Mohamed Amine (2017)
Framed by Pr Essya Bel Hassan (CNGMO Bacteriology Laboratory)
In cooperation with the FMT Experimental Medicine Unit - 5- Study of the effect of a new thioamide on pain
Prepared by Amal Ben Othman
Framed by Pr Michele El May
Masters subjects
- 1- Evaluation of the toxic effect of cadmium provided by food and demonstration of the antioxidant effect of green tea in the Wistar rat.
Created and supported by the student : Soumaya Glid
Framed by Dr Ali Ben Amor (FMT Work Medicine Laboratory)
Co-supervised by the health school
In cooperation with the FMT Experimental Medicine Unit - 2- Induction of experimental colitis in Wistar rats with a hapten and anatomopathological study of the colonic mucosa.
Created and supported by the student : Naouar Mostafa Sadek
Framed by Pr Lilia Mekki (FMT Physiology Laboratory)
In cooperation with the FMT Experimental Medicine Unit - 3- Study of two newly synthesized molecules, thioamide and 3-5; diaminopyrazole: toxicology and effects on the behavior of Wistar rats.
Created and supported by the student : Ben Othman Amal
Framed by Pr Michele El May (FMT Histology and Embryology Laboratory)
Co-supervised by Pr Azeiz Ben Akacha (Laboratoire de chimie fine de FST)
In cooperation with the FMT Experimental Medicine Unit - 4- Evaluation of the antibacterial effect of green clay and its effect on the intestinal flora in the Wistar rat.
Created and supported by the student : Brahmi Souhaieb
Framed by Pr Michele El May (FMT Histology and Embryology Laboratory)
Co-supervised by Pr Essya Bel Hassan (CNGMO Bacteriology Laboratory)
In cooperation with the FMT Experimental Medicine Unit
Engineering PFE topics
- 1- Evaluation of the nutritional health benefits of a fermented functional food.
Created and supported by the student : Miladi Hasna
Framed by Pr Salwa Jamelleddine (FMT Physiology Laboratory)
Co-supervised by INSAT
In cooperation with the FMT Experimental Medicine Unit - 2- Effects of bioactive molecules on experimental pulmonary fibrosis in the Wistar rat: effect of essential oils of cypress and lentisk.
Created and supported by the student : Ben Chalbi Wissal
Framed by Pr Salwa Jamelleddine (FMT Physiology Laboratory)
In cooperation with the FMT Experimental Medicine Unit
License PFE
- 1- Synthesis and study of the toxicity of a thioamide derivative and 3,5-diaminopyrazole.
Created and supported by the student : Kaouther Ben Hamouda and Marwa Mahfoudhi
Framed by Pr Michèle El May (FMT Experimental Medicine Unit) 2015/2016
Co-supervised by Pr Azeiz Ben Akacha (FST Fine Chemistry Laboratory) - 2- Study of the effect of hypericum humifusum on oxidative stress in the Wistar rat.
Created and supported by the student : Moez Moncer and Jalel Khalfi
Framed by Dr Hammami Imen (FMT Experimental Medicine Unit) 2015/2016 - 3- Study of the effect of hypericum humifusum on spermatogenesis in the Wistar rat: Histological and biochemical study. 2015/2016
Created and supported by the student : Riahi Nawres
Framed by Dr Hammami Imen (FMT Experimental Medicine Unit) - 4- Protection by Rhamnus Alaternus against the deleterious effects of total ischemia / reperfusion of the liver in rats. 2015/2016
Framed by Ridha Ben Ali (FMT Experimental Medicine Unit) - 5- Development and validation of a colorimetric assay method for thioamide derivatives.2017/2018.
Nada Jaouadi and Ghofrane Nejri
Framed by Pr Michele El May and Ridha Ben Ali (FMT Experimental Medicine Unit) - 6-Synthesis and evaluation of the antioxidant, analgesic, and anti-inflammatory power of phosphonoamidate and phosphonothioamidate derivatives. 2017/2018
Arbia Younes
Framed by Pr Michele El May and Ridha Ben Ali (FMT Experimental Medicine Unit)
Publications
- A 1: Ridha Ben Ali, Amal Ben Othman, Khouloud Bokri, Samira Maghraoui, Adel Hajri, Azaiez Ben Akacha, Chadli Dziri, Michele Veronique El May.Synthesis and evaluation of analgesic, behavioral effects and chronic toxicity of the new 3,5-diaminopyrazole and its precursor the thiocyanoacetamide. Biomedicine & Pharmacotherapy 86 (2017) 109–117.
- A 2 :Ridha Ben Ali, Anouar Ounis,, Dorra Ben Said, Chadli Dziri, Michele Veronique El May. Gastroprotective effects of Tunisian green clay on ethanol-induced gastric mucosal lesion in rats. Applied Clay Science 149 (2017) 111–117
- A 3 : Sana Bahri, Ridha Ben Ali, Khaoula Gasmi, Mona Mlika, Saloua Fazaa, Riadh Ksouri, Raja Serairi, Saloua Jameleddine et Vadim Shlyonsky.
Prophylactic and curative effect of rosemary leaves extract in a bleomycin model of pulmonary fibrosis. Pharmaceutical Biology • January 2017. DOI: 10.1080/13880209.2016.1247881 - A 4 : Marwa Bousaada, Ridha Ben Ali, Azaa Ben Said, Khouloud Bokri, Azaiez Ben Akacha, Chedli Dziri, Michele Veronique El May.
Selenium and a newly synthesized Thiocyanoacetamide reduce Doxorubicin gonadotoxicity in male rat. Biomedicine & Pharmacotherapy 89 (2017) 1005–1017 - A 5: Imen Hammami, Ridha Ben Ali, Afef Nahdi, Olfa Kallech-Ziri, Marwa Boussada, Ahmed El May, Michele Veronique El May.
Chronic consumption of Hypericum humifusum leaf extracts impairs epididymis spermatozoa characters in association with oxidative stress in adult male Wistar rats.
Biomedicine & Pharmacotherapy 93 (2017) 616–625 - A 6: Sana Bahri, Ridha Ben Ali, Anouar Abidi, Saloua Jameleddine.
The efficacy of plant extract and bioactive compounds approaches in the treatment of pulmonary fibrosis: A systematic review.
Biomedicine & Pharmacotherapy 93 (2017) 666–673 - A 7 : Ridha Ben Ali, Sohaib Brahmi, Mohamed Amine Mekni, Anis Raddaoui, Anouar Ounis, Chadli Dziri, Michele Veronique El May
Evaluation of the antibacterial activity of Tunisian green clay and its effect on the intestinal flora in the Wistar rat
Review F.S.B XV 2016-2017, 159-166 - A 8 : Nedra Badri, Maroua Mhamdi, Ridha Ben Ali, Horea Matei, Walid-Habib Tekaya, Adrian Florea, Samira Maghraoui, Leila Tekaya. Gold and Female Reproductive Organs: an Ultrastructural Study. Biol Trace Elem Res, DOI 10.1007/s12011-017-1135-7
- A 9 : Sana Bahri, Frederique Mies, Ridha Ben Ali, Mona Mlika, Saloua Jameleddine,
Kathleen Mc Entee, Vadim Shlyonsky. Rosmarinic acid potentiates carnosic acid induced apoptosis in lung fibroblasts. PLOS ONE | https://doi.org/10.1371/journal.pone.0184368 September 6, 2017 - A 10: Anouar Abidi, Raja Serairi, Nadia Kourda, Ridha Ben Ali, Saloua Ben Khams and Moncef Feki. Therapeutic effect of flaxseed oil on experimental pulmonary fibrosis induced by bleomycin in rats. European Journal of Inflammation. 2016, DOI: 10.1177/1721727X16652147
- A11. Afef Nahdi, Imen Hammami, Ridha Ben Ali, Olfa Kallech-Zirib, Ahmed El May, Michele Veronique El May. Effect of Hypericum humifusum aqueous and methanolic leaf extracts on biochemical and histological parameters in adult rats. Biomedicine & Pharmacotherapy 108 (2018) 144–152.